This finding has been recently confirmed by Shibazaki and colleagues [18] who described an optimal cutoff concentration of plasma BNP level to distinguish CE from other stroke subtypes of 140.0 pg/mL, and extended to pro-BNP by Rodríguez-Yáñez and collaborators [19], who studied 262 patients with first ischemic stroke within the first 12 hours, showing that pro-BNP >360 pg/mL was independently associated with CE stroke (OR=28.51, 95% CI, 5.90-136.75, P< 0.0001). This evidence concerns the gene NPPB and cholesteryl ester measurement.