In addition, p53 has been shown to transactivate the caspase-8 promoter [47], and p53-mediated up-regulation of caspase-8 and sensitization toward death receptor-mediated apoptosis was observed in certain tumor cell lines with down-regulated caspase-8 as well as TRAIL-resistant primary tumor cells following drug treatment [48]. The gene discussed is CASP8; the disease is neoplasm.