Although the diseases studied were different, our results were also consistent with the findings of previous studies which showed that the TNF-α inhibitor reduced Th17 cell responses with the amelioration of psoriatic skin lesions [38] and that the TNFR1 inhibitor suppressed the Th17 response with clinical benefits in experimental autoimmune encephalomyelitis mice [39]. The gene discussed is TNF; the disease is experimental autoimmune encephalomyelitis.