We attempted to apply a scoring system that reflected the tumor-associated increase in expression of Her2 and Her3, using cut-offs of greater than or equal to +1 (range 0 to +3)for membranous staining of Her2 and Her3, and greater than or equal to 3 (range 0 to 12) for cytoplasmic expression of Her3. This evidence concerns the gene ERBB3 and neoplasm.