For screening of our in-house compound libraries the human glioblastoma cell line U343 was used, because glioblastoma cell lines were shown to respond with increased IL-6 expression to different neuroinflammatory stimuli like LPS [27], Substance P [46], tumor necrosis factor α, interleukin-1β, leukemia-inhibitory factor and OSM [30]. Here, TNF is linked to glioblastoma.