P-OPG was positively associated with age (r = 0.26, p < 0.001), diabetes duration (r = 0.18, p = 0.010), vibration threshold (r = 0.24, p < 0.001), and P-NT-proBNP (r = 0.27, p < 0.001), while inversely related to increased heart rate variation (r = -0.20, p = 0.007). The gene discussed is NPPB; the disease is diabetes mellitus.