However, most data comparing clinical features between BMPR2 mutation carriers and non-carriers have been obtained from registries as from the French Network of Pulmonary Hypertension [6,13-15], and from centres in the United States as the New York Presbyterian Pulmonary Hypertension Center [12], the Utah Pulmonary Hypertension Genetics Project [16] or the Vanderbilt University School of Medicine, Nashville, Tennessee [7,17,18] and are retrospective in design. The gene discussed is BMPR2; the disease is pulmonary arterial hypertension.