Killing of pancreatic cancer cells by CDDO-Me was associated with an increase in annexin-V-FITC binding, cleavage of PARP-1 and procaspases, mitochondrial depolarization, release of cytochrome C, and inhibition of prosurvival/progrowth signaling proteins such as p-Akt, NF-κB and p-mTOR. The gene discussed is AKT1; the disease is familial pancreatic carcinoma.