ITGAX and systemic lupus erythematosus: Flow cytometry analysis of the presence of myeloid cells showed that pSAP-treated lupus mice exhibited a notable decrease in the number of F4/80+ macrophages (Fig. 6A), but there was no significant decrease in the number of CD11c+ dendritic cells (data not shown), suggesting that macrophages were the key cells that was influenced by pSAP treatment.