It was not surprising to find limited overlap of only 6 of 150 in IOSE, 6 of 92 in HaCaT, and 1 for all three studies in common with the 318 SMAD4 target genes in this study (Figure 3A) as only one, A2780, is a cancer cell line and the other two are normal cell lines. This evidence concerns the gene SMAD4 and cancer.