CDKN1C and breast carcinoma: By careful examination of the individual miRNAs that negatively correlated with the expression levels of their target genes, we found that miR-367 (belonging to the miR-302-367 cluster mentioned above) was up-regulated solely in TGCT and its predicted target CDKN1C, an imprinted gene which is characterized by frequent loss of imprinting in esophageal and breast cancers, was also down-regulated in TGCT (r = -0.59, P = 0.024) [26], [27].