In order to further explore this marked prognostic value of the KRT81 rs3660 genotype in squamous cell carcinoma, we analyzed KRT81 expression by immunohistochemistry in 42 squamous cell carcinoma, 33 adenocarcinoma and 2 adenosquamous carcinoma samples and in three normal lung tissue samples. This evidence concerns the gene KRT81 and squamous cell carcinoma.