HIF1A and myeloid leukemia: However, it has been reported that mitogen-activated protein (MAP) and extracellular signal-regulating kinase (ERK) kinase (MEK) as well as phosphoinositide 3-kinase (PI3 kinase) but not p38 MAP kinase, play a role in SCF-induced HIF-1α accumulation in human myeloid leukaemia cells [5].