To test whether mutations in LRRK2 cause an alteration in basal gene expression we have examined the impact of mutations in three contexts: fibroblast cells cultured from PD patients carrying mutations in LRRK2 (including the R1441G, Y1699C and G2019S mutations), brain tissue from 5 patients carrying the G2019S mutation compared to idiopathic PD and control brain tissue [10], and HEK293T cells stably transfected with a plasmid allowing inducible expression of LRRK2 with or without the R1441C mutation. The gene discussed is LRRK2; the disease is Parkinson disease.