ENPP2 and cancer: Therefore, we conclude that LPA1 and LPA3 on vascular endothelial cells are molecular targets for radiosensitization and tumor control as endothelium plays a vital role in tumor growth and invasion, Based on the published literature, in addition to inhibiting LPA1 and LPA3 on endothelial cells, BrP-LPA could also function by inhibiting ATX and LPA receptors on cancer cells (Fig. S1).