To carryout these experiments, tissue sections from lymphoma invaded lung, liver and thymus in the terminal ESPL1+/hyp, p53−/− mice as well as tissues affected by various carcinomas (colon, mammary and salivary) in the ESPL1+/hyp, p53+/− mice were stained with Separase antibody. The gene discussed is ESPL1; the disease is carcinoma.