TP53 and B-cell non-Hodgkin lymphoma: It is conceivable that reduction of Separase levels along with loss of p53 results in the accumulation of DNA damage and aneuploidy in an independent subset of hematopoietic cells (from those affected by loss of p53 alone), resulting in the appearance of a more widespread T- and B-cell lymphoma phenotype as well as bone marrow involvement.