NOS2 and neoplasm: Looking at NM staining for each protein, there was an inverse relationship between tumour islet density and survival for NM-VEGF (p<0.001), and significant positive associations for NM-HLA-DR (p<0.001), NM-iNOS (p = 0.003) and NM-MRP 8/14 (p = 0.04) (Fig. 4).