Non-macrophage (NM) expression of CD163 (NM-CD163) in the tumour islets was similar when compared between ES and PS patients (median 3.9 versus 5.2 cells/mm2 respectively, p = 0.39), but expression of NM-VEGF was significantly reduced in the ES compared to PS patients (2.1 versus 11.4 cells/mm2 respectively, p<0.001). This evidence concerns the gene VEGFA and neoplasm.