Increased activation of STAT3 was observed in SLE, RA T cells (SLE 3.584±0.1243, RA 3.620±0.2553, HD 3.034±0.1026, SLE vs HD, P<0.01, RA vs HD P<0.05, Figure 1A, Revised Figure 2A). This evidence concerns the gene STAT3 and systemic lupus erythematosus.