No significant differences was found in either the clinical manifestations, such as rash, arthritis, vasculitis, oral ulcers, proteinuria, white blood cells, and hemoglobin, or the autoantibody profiles, including anti-Ro, anti-U1 RNP, anti-Sm, and anti-dsDNA, of the two groups. The gene discussed is CALR; the disease is arthritic joint disease.