Our previous studies revealed its increased shedding from placental surfaces into maternal blood in patients with preterm severe preeclampsia and HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome [33], [34], a phenomenon that may be responsible for elevated maternal serum PP13 concentrations in these patients in the second half of pregnancy [21], [33]. The gene discussed is LGALS13; the disease is preeclampsia.