The current view on preeclampsia suggests that preeclampsia has an exaggerated maternal systemic immune response component [12], [57], [58], and indeed, blood-group antigens influence the bioavailability of E-selectin, TNF-alpha and ICAM1 [59], factors implicated in the pathogenesis of preeclampsia [60]. The gene discussed is ICAM1; the disease is preeclampsia.