This is important since the origins of preeclampsia can be dated back to the very early events in placentation [11], [12], [57], [58], and the reduced first trimester placental expression of PP13, a galectin that may have important immunobiological functions at the maternal-fetal interface [28], [64], may contribute to the early events in the placental pathogenesis of preeclampsia in these patients. The gene discussed is LGALS13; the disease is preeclampsia.