Therefore, the objectives of this study were to 1) determine the relation between maternal serum PP13 and maternal blood groups throughout pregnancy; 2) confirm the differential binding of PP13 to RBCs of various ABO blood types; and 3) investigate whether the adjustment of maternal serum PP13 multiples of the medians (MoMs) to maternal blood groups could improve the predictive value of the PP13 test for preeclampsia and IUGR. This evidence concerns the gene LGALS13 and preeclampsia.