TGFB1 and muscular dystrophy: Finally, latent TGFβ-binding protein (LTBP)4 regulates the release and bioavailability of TGFβ from the ECM, where it has been shown to modulate fibrosis in the context of muscular dystrophy in mice [77] Taken together, these studies highlight the crucial role of TGFβ in the initiation of fibrotic processes, and in the induction of differentiation of myogenic cells into myofibroblastic cells in injured muscle.