More than 70 different mutations in RYR2, the gene encoding the cardiac isoform of RyRs, have been associated with CPVT [141], which is characterized by: a) more than two types of ventricular tachycardia morphologies, b) absence of underlying organic heart disease and c) absence of primary electrical disease (long QT, Brugada syndrome) [142]. Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia.