LAMA2 and congenital muscular dystrophy: It is now well established that laminin-211 is the main laminin isoform in skeletal muscle [8,9], and identification of laminin α2 chain mutations in a severe form of congenital muscular dystrophy (merosin-deficient congenital muscular dystrophy; MDC1A) showed the importance of laminin-211 for normal muscle function [10].