Proteomic screening of the x-linked muscular dystrophy (mdx) animal model of Duchenne muscular dystrophy revealed that the deficiency in dystrophin is associated with altered levels of metabolic enzymes (adenylate kinase, carbonic anhydrase, isocitrate dehydrogenase), Ca2+-regulatory proteins (regucalcin, calsequestrin) and molecular chaperones (cardiovascular heat shock protein cvHsp). The gene discussed is RGN; the disease is Duchenne muscular dystrophy.