Intriguingly, we observed a significant increase in MyHC-IIb mRNA in Duchene muscular dystrophy (DMD) leg muscle biopsy samples compared with leg muscle biopsy samples from healthy control subjects or patients with muscular dystrophies not characterized by rounds of degeneration and regeneration [limb-girdle muscular dystrophy (LGMD) or spinal muscular atrophy (SMA); Figure 3d]. The gene discussed is MYH4; the disease is limb-girdle muscular dystrophy.