Intriguingly, we observed a significant increase in MyHC-IIb mRNA in Duchene muscular dystrophy (DMD) leg muscle biopsy samples compared with leg muscle biopsy samples from healthy control subjects or patients with muscular dystrophies not characterized by rounds of degeneration and regeneration [limb-girdle muscular dystrophy (LGMD) or spinal muscular atrophy (SMA); Figure 3d]. Here, MYH4 is linked to muscular dystrophy.