As PTEN is a well-established tumor suppressor and acts as a negative regulator of the PI3K/AKT pathway, and we found that Evi1 activated the AKT/mTOR signaling pathway through transcriptional repression of PTEN. The activation of this signaling is essential for Evi1-mediated leukemogenesis, as discussed later. Here, RUNX1 is linked to neoplasm.