Considering the above-mentioned observations in mice, rats, and humans, it will be worthwhile to address off-target effects of cathepsin K inhibitors on the CNS of patients, since a dopaminergic induction similar to the one observed in this study could help in the treatment of neurodegenerative disorders, such as Parkinson's disease, in addition to managing the symptoms of osteoporosis. The gene discussed is CTSK; the disease is Parkinson disease.