In order to assess the tissue-specific contributions of liver, skeletal muscle, and adipose tissue to whole-body insulin resistance in the HFD-fed ApoC3Tg mice, we performed hyperinsulinemic-euglycemic clamp studies combined with 3H/14C-labeled glucose infusions.16, 17 Overnight fasting plasma glucose and insulin concentrations were similar between the two groups (Table 1) as were basal rates of endogenous glucose production (EGP) (Fig. 2E). Here, INS is linked to Insulin resistance.