VEGFA and rheumatoid arthritis: VEGF is not only one of the most important angiogenesis factors, but is involved also in inflammatory processes in OA and contribute to symptoms such as pain and swelling by targeting the synovial membranes [31–34], chronic inflammatory responses are often associated with the production of angiogenic factors that induce vascular proliferation, and in rheumatoid arthritis VEGF is highly expressed in synovial cells [35–40].