In accordance with the previous results, we found that BYHWD (25.68 and 12.84 g kg−1) reduced the expression of CD40 in the mononuclear cells and inhibited the expressions of CD40 and CD40L in myocardial tissues, which suggests that the roles of BYHWD on myocardial ischemia may be related to the inhibition of CD40 and CD40L expressions. The gene discussed is CD40LG; the disease is myocardial ischemia.