AKT1 and cancer: We have previously demonstrated that ErbB3, a member of the EGFR family of receptor tyrosine kinases, has a pivotal role in pancreatic tumourigenesis through heterodimerisation with EGFR and induction of phosphoinositide 3-kinase (PI3K)/AKT signalling, which promotes in vitro and in vivo cancer cell proliferation (Liles et al, 2010).