Moreover, 3-hydroxybutyrate did not modify cell death induction by activation of the mitochondrial apoptotic pathway via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL; Figure 4C and data not shown), or inhibition of clonogenic cell growth by temozolomide, the adjuvant standard of care chemotherapeutic agent in glioma patient treatment (Figure 4D and data not shown). Here, TNFSF10 is linked to central nervous system cancer.