EGFR and Anorexia: Overall, the incidence and severity of the most frequently occurring motesanib-related adverse events (diarrhea, nausea, vomiting, fatigue, and anorexia) were consistent with those observed in other studies of motesanib as monotherapy [16,17], in combination with chemotherapy [18], and in combination with an EGFR inhibitor and chemotherapy [20,24].