ORMDL3 and asthma: For instance, Moffatt et al. (2007) found that the most significant SNPs associated with childhood asthma risk in a large LD region with 19 candidate genes accounted for 29.5% of the variance of ORMDL3 transcript levels measured in lymphoblastoid cell lines (LCLs) and thus ORMDL3 was prioritized as a primary biological candidate for the asthma locus [5].