Supporting this notion, our recent study indicated that CD19+ CD27+ cells (memory B cells [44]) are recruited to the liver of patients with CHC through the interaction between CXCR3 expressed on CD19+ CD27+ cells and IP-10 (IFN-γ-inducing protein 10 kD) produced in the liver [45]. The gene discussed is CD27; the disease is cryohydrocytosis.