Hepatocellular carcinomas (HCCs) overexpress several angiogenic proteins, including vascular endothelial growth factor-A (VEGF-A) [1-3], VEGF-D [4], and platelet-derived endothelial growth factor (PDGF) [2], as well as expressing receptors to these ligands (comprising VEGF receptors [VEGFRs]-1, -2 [5], and -3 [4]). The gene discussed is VEGFD; the disease is hepatocellular carcinoma.