The aim of the present study was to assess the role of MCTs in prostate cancer, by comparing the immunohistochemical expression of the MCT isoforms 1, 2 and 4, along with CD147 and gp70, in normal prostatic tissue, adjacent non-neoplastic tissue, PIN lesions and neoplastic tissues in a large series of prostate samples organized into tissue microarrays (TMAs), and evaluating their clinico-pathological value. This evidence concerns the gene EMB and prostate cancer.