CXCL12 and pancreatic neoplasm: Another study demonstrated that most pancreatic cancer cells (PaCa) and their stromal fibroblasts express CXCR4 and PaCa-derived CXCL8/IL-8 and fibroblast-derived CXCR12/SDF-1 cooperatively induced angiogenesis in vitro by promoting human umbilical vein endothelial cells (HUVECs) proliferation, invasion and tube formation [23].