GAD114-122-specific CD8+ T cells, as well as GAD-specific and insulin-specific CD4+ T cells, have further been detected exclusively in T1D patients within the memory CD45RO+ T cell population while naïve CD45RO T cell stained with HLA-0201*-GAD114-122 tetramers were discriminative between control and T1D patients [101]. Here, GAD1 is linked to type 1 diabetes mellitus.