Analysis of CTA expression in the neuroectodermal cancer lines has shown that MAGE-A8, MAGE-B2, and MAGE-A3, -A6 together with MAGE-D1, -D2 are expressed in most cell lines tested whereas the early neuroectodermal cells derived from hES cells expressed only MAGE-A4 and MAGE-D1, 2. Here, MAGEA8 is linked to cancer.