Besides, the endothelial progenitor cells (EPCs), a tissue engineer to reconstruct pulmonary vasculature, have been used to protect the tissue from ALI manipulated with gene transfer (such as nitric oxide, prostacyclin, and adrenomedullin) [15] since dysfunction of pulmonary vascular endothelium may play a role in the pathogenesis of pulmonary hypertension associated with ALI/ARDS. The gene discussed is ADM; the disease is acute respiratory distress syndrome.