Finally, mutations in the Rho associated coiled-coil containing protein kinases (ROCK1 and ROCK2) are interesting in view of their role as effectors of RhoA GTPase and the recent finding that truncating mutations in ROCK1 (similar to the confirmed ROCK2 mutation in this study) are activating and lead to increased motility and adhesion in cancer cells [99]. The gene discussed is ROCK1; the disease is cancer.