PEA15 and diabetes mellitus: Thus, considering the different known cellular function of PED/PEA-15 in a chronic disorder such as diabetes (Condorelli et al., 2001; Vigliotta et al., 2004; Valentino et al., 2006), the observation that PED/PEA-15 regulates fibroblast motility may have a significant impact on future investigation of its role in diabetic complications.