This is in line with our finding that the ALDH+ stem cell-like cells from prostate cancer cell lines expressed active STAT3 and that these ALDH+ cells responded to the STAT3 inhibitor galiellalactone, which has previously been shown to induce apoptosis of prostate cancer cells with constitutive expression of active STAT3 [22]. This evidence concerns the gene STAT3 and Familial prostate cancer.