F7 and hepatocellular carcinoma: In addition, our protein profile data revealed a 6.4- to 22.2-fold down-regulation of coagulation factors such as fibrinogen and factor VII, concerning the ratio of GLV-1h68 treated/untreated PLC human hepatoma xenografts when compared with the ratio of GLV-1h68 treated/ untreated HuH7 human hepatoma xenografts at 10 dpi (Table 2).