CD8 depleted mice presented higher parasitemia (Fig. 7A and B) and shorter survival times (Fig. 7C and D) when compared to A/Sn mice vaccinated with heterologous prime-boost regimen (pIgSPCl.9/AdASP-2 or pIgSPTAWETGQA/AdTAEWTGQA) and treated with rat IgG. This evidence concerns the gene CD8A and parasitic infectious disease.