For example, CAST/EiJ mice exhibit decreased rod function correlating with significantly diminished expression of NYCTALOPIN (NYX) which models human retinal disease as human mutations in NYCTALOPIN are associated with phenotypes associated with impaired rod function, decreased a-wave amplitude, X-linked retinoschisis, and X-linked congenital stationary night blindness [60]-[62]. This evidence concerns the gene CAST and X-linked retinoschisis.