Here we show that VEGF is indeed essential to maintain SEC fenestrations and HSC quiescence and that, correspondingly, mere blockade of endogenous VEGF is sufficient to cause sinusoidal capillarization which, in turn, leads to PH and its sequela, including ascites, splenomegaly and the development of venuous collateral circulation. This evidence concerns the gene VEGFA and Splenomegaly.