Each of these auto-antibodies is a marker for relatively distinct clinical subgroups of SSc, with anti-centromere typically associated with limited cutaneous disease, uncommon pulmonary fibrosis, late-onset pulmonary hypertension but generally an overall good prognosis, while ATA is a marker for diffuse skin disease and clinically significant pulmonary fibrosis with a resultant poorer prognosis. The gene discussed is ATM; the disease is systemic sclerosis.