NFKB1 and asthma: However we find that RV induction of IFN-α, IFN-β and IL-15 are all profoundly suppressed by inhibition of NF-κB. These data suggest that administration of such inhibitors in asthma, while inhibiting pro-inflammatory mediator production, is likely to further impair deficient type I IFN and IL-15 production, and therefore might have potential to increase rather than decrease severity of virus induced asthma exacerbations.