Since (i) α/βIFNs are reported to induce IL-15 in dendritic cells and monocytes [14], [15], (ii) RV induction of IFN-β is reported deficient in asthma [4], (iii) IL-15 is important in innate and acquired antiviral immunity and (iv) there is increased susceptibility to RV infection in asthma [1]–[3] we hypothesized that IL-15 production may be deficient in asthma and related to asthma exacerbation pathogenesis. The gene discussed is IL15; the disease is asthma.