Our findings also have important implications for development of type I IFNs as potential therapies for asthma exacerbations, as we show that RV infection of macrophages induces α/β IFNs, that IL-15 is induced by IFN-β stimulation and that RV induction of IL-15 in macrophages is dependent on IFN-α/β receptor signalling. The gene discussed is IFNB1; the disease is asthma.