ATXN2L and neuropathy: In models of neuropathy and ostearthritis, gabapentanoid modulation depends on the permissive pathological state involving specific interactions with descending serotonergic facilitations mediated by brainstem-spinal mechanisms and hypothesized interplay between presynaptic 5-HT3 receptors and α2δ subunits of voltage-gated calcium channels [5,46].